12th Forum – Bangkok, Thailand, 28-29 November 2017

Theme of the Meeting
Ethics of alternative clinical trial designs and methods in LMIC research
The Wellcome Trust and Mahidol Oxford Tropical Medicine Research Unit


Supported by:

  • The Wellcome Trust
  • Medical Research Council-United Kingdom (MRC UK)
  • Bill & Melinda Gates Foundation
  • National Institutes of Health

Planning Committee

Members of the Planning Committee for this meeting were:

  • Phaik Yeong Cheah, The Mahidol Oxford Tropical Medical Research Unit (MORU), Thailand;
  • Nicholas Day, MORU, Thailand;
  • Katherine Littler, Wellcome Trust, UK;
  • Patricia Njuguna, KEMRI-Wellcome Trust programme, Kenya;
  • Annette Rid, King’s College London, UK;
  • Patricia Saidón, Instituto de Investigación en Salud Pública (IDISA), Argentina;
  • Ross Upshur, University of Toronto, Canada;
  • Rieke van der Graff, University Medical Center Utrecht, Netherlands;
  • Charles Weijer, Western University, Canada.


Programme and Presentations

Programme details

Click here to view the conference booklet, including case study summaries.



Videos of the presentations will be available in March 2018.


Keynote: HIV prevention trials in the era of PREP: Impact on trial designs and the ethics of standard of care in low/middle income settings
Glenda Gray, South African Medical Research Council


Theme 1: Cluster randomised trials


Theme 2: Stepped wedge


Theme 3: Adaptive platforms


Pecha Kucha


Summary of day 1


Theme 4: Controlled human infection models


Theme 5: Current guidance and regulation: Regional perspectives


Theme 6: Current guidance and regulation: Gaps and creative solutions

  • Informing ethical evaluations of adaptive clinical trials through simulation
    Roger Lewis, University of California, USA
  • Panel and open discussion (video only):
    • Rieke van der Graaf, University Medical Centre Utrecht, Netherlands
    • Roger Lewis, University of California, USA
    • Phaik Yeong Cheah, Mahidol Oxford Tropical Medicine Research Unit, Thailan
    • Charles Weijer, Western University, Canada
    • Patricia Saidon, Instituto de Investigación en Salud Pública Argentina


Key themes panel (video only)

  • Paul Ndebele, Medical Research Council, Zimbabwe
  • Anant Bhan, Yenepoya Medical College, India
  • Carla Saenz, Pan American Health Organisation, USA
  • Rachel Knowles, Medical Research Council, UK
  • Mike Parker, Oxford University, UK


Conclusions, presentation of poster award and GFBR award (video only)

  • Paul Ndebele, Medical Research Council, Zimbabwe and Anant Bhan, Yenepoya Medical College, India

A background paper was prepared in advance of the meeting and provides an overview of the field and the key ethical issues raised by this important topic.

A meeting report is available, along with a slide deck that participants are very welcome to use when presenting on the meeting back home.

In addition, the papers from this meeting were published in a two part Supplement in Trials. Part 1 contains an Editorial, the meeting summary and papers on stepped wedge cluster randomised trial design and controlled human infection models. Part 2 contains a paper on cluster randomised trials.

We are very interested to hear about participants’ post-meeting activities. Please do keep us up-to-date by emailing gfbr@wellcome.ac.uk.

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